Depression of hepatic dolichol levels by cholesterol feeding.
A study was conducted to determine whether repression of 3-hydroxy-3-methylglutaryl CoA reductase by a chronic high-cholesterol diet would deplete hepatic dolichol levels.Four-week-old male C57BL/6J mice were maintained on a control diet or a diet supplemented with 5% cholesterol.Animals from both groups were killed at various times and reductase a